Based on human, animal, and in vitro studies, as well as family interviews, I hypothesize that diethylstilbestrol DES, along with several other toxic substances, can damage the genomic information in early fetal-stage gametes.
... See MoreSee Less, Share on FacebookShare on TwitterShare on Linked InShare by Email. We recently published findings for cardiovascular disease risk in the Combined DES Cohort Follow-up Study participants. The incidence of CCAC of the vagina and cervix in the population is bimodal, with a second peak at older age. If any pills were taken during pregnancy, obstetrical records should be checked to determine the name of the drug.
They also may have higher rates of infertility and fewer live births. It is still unknown if at this age DES daughters will have an increased incidence of these malignancies. Three of the daughters were delivered from one mother. Because Social Media increases Awareness and brings the DES Community Together, Aattention-Deficit/Hyperactivity Disorder Much More Common in Grandchildren of Women Who Were Prescribed the DES Drug in Pregnancy. Several million people have been exposed to DES, most without knowing it. The daughters in this study were, however, on average, in their late 30s and had not reached the age at which we expect cancer to occur so we are continuing to monitor these women. A study published in 2003 found little support for the hypothesis that in utero exposure to DES influences the psychosexual characteristics (the likelihood of ever having been married, age at first intercourse, number of sexual partners, and having had a same-sex sexual partner in adulthood) of adult men and women. From animal experiments it becomes clear that DES administration to pregnant mice results in an increased incidence of genital tumours not only in the second generation but also in the third. on Much Higher Risk of ADHD in DES GrandChildren. University of California at Los Angeles Medical Center, University of Massachusetts Medical School. Answers to other questions about DES can be found on the following web sites: This information is not meant to be a substitute for professional medical advice. You will receive helpful replies to your questions from our members. If you were born between 1938 and 1971, if your mother had problems with any of her pregnancies or remembers taking anything when she was pregnant with you, you could have been exposed. OBJECTIVE: To examine a group of women (third-generation daughters) whose mothers were exposed in utero to diethylstilboestrol (DES) and compare their findings on pelvic examination with those noted in their mothers. None of the third-generation daughters were found to have changes usually associated with DES exposure. Then you may be a DES Grandchild and should pay attention to that possibility. Association of Exposure to Diethylstilbestrol During Pregnancy With Multigenerational Neurodevelopmental Deficits. When we first began our DES studies, we suggested that a colposcopic examination be done each year.
Cervical dysplasia (abnormal cell change) is more common among DES daughters, but normal cell changes may be mistakenly seen as abnormal when your cervix is checked, leading to unnecessary treatment with possibly harmful effects. If you are a DES daughter over age forty, your risk for breast cancer may be almost two times greater than that of unexposed women. When given during the first 5 months of a pregnancy, DES can interfere with the development of the reproductive system in a fetus. Support Research into the Far-Reaching Generational Toxicity of DES, germline exposures, 10/10/2016. The DES problem continues to be an important issue.
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