Recombinant erythropoietin alfa has been evaluated as adjunctive treatment for severe pregnancy associated iron deficiency anemia (Breymann 2001; Krafft 2009) and has been used in pregnant females with iron-deficiency anemia associated with CKD (Furaz-Czerpak 2012; Josephson 2007). Epoetin alfa is not indicated for use under the following conditions: - Cancer patients receiving hormonal therapy, therapeutic biologic products, or radiation therapy unless also receiving concurrent myelosuppressive chemotherapy, - Cancer patients receiving myelosuppressive chemotherapy when the expected outcome is curative, - Cancer patients receiving myelosuppressive chemotherapy when anemia can be managed by transfusion, - Surgery patients who are willing to donate autologous blood, - Surgery patients undergoing cardiac or vascular surgery, - As a substitute for RBC transfusion in patients requiring immediate correction of anemia. Sign in or Register a new account to join the discussion. Darbepoetin alfa stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Erythropoietin - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Your doctor will need to watch your blood cell counts and follow you closely to change the dose to match your body's needs.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. All trademarks used are the properties of their respective owners. Shortness of breath, a big weight gain, or swelling in the arms or legs. Last updated on May 21, 2020. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more.
When the box is full, follow all local rules for help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Additional data may be necessary to further define the role of epoetin alfa for this situation. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
RBC transfusion refusal (substitute) (off-label use): Note: Concomitantly administer iron (with or without vitamin B12 and folic acid supplementation) with epoetin alfa and use in conjunction with other blood conservation techniques. However, many people have no side effects or only have minor side effects.
It may be given to you for other reasons. - Uncontrolled hypertension. Tell your doctor about the allergy and
The manufacturer recommends supplemental iron be administered if serum ferritin is <100 ng/mL or serum transferrin saturation (TSAT) is <20%. In patients with CKD on hemodialysis, the IV route is recommended. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this site. - Anaemia associated with chronic renal failure in adults on peritoneal dialysis. ESAs should not be used when the intent of cancer chemotherapy is curative. If you think there has been an overdose, call your poison control center or get medical care right away. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. This medicine is screened, tested, and ‘The CNOs have made a powerful statement on nurse mental health and Covid-19’. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. Renal cortex peritubular cells produce most EPO in the human body, though in a fetus, the liver is the primary site of production. All rights reserved. The product information provided by this site is intended only for health care professionals, patients, consumers and caregivers in the United States. CKD patients who exhibit an inadequate Hb response to ESA therapy may be at a higher risk for cardiovascular events and mortality compared to other patients.
Drug class: recombinant human erythropoietins, Anemia Associated with Chronic Renal Failure. Anemia due to chronic kidney disease: Treatment of anemia due to chronic kidney disease, including patients on dialysis and not on dialysis, to decrease the need for RBC transfusion. High blood pressure has happened with this medicine (epoetin alfa vials). Do not freeze. Throw away needles in a needle/sharp disposal box. Erythropoietin is required for the transformation of the most mature erythroid progenitor cell, erythroid colony-forming unit (CFU-E), to a proerythroblast. Due to increased risk of DVT, DVT prophylaxis is recommended. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Available for Android and iOS devices. Medical information for Darbepoetin Alfa on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose. Read all information given to you. How many biosimilars have been approved in the United States?
• Treatment of anemia associated with chronic kidney disease. - The dose will vary according to preparation and body weight. Under 5 years: Safety and efficacy not recommended. Check with your physician if you have any of the following: - The two types of erythropoietin, epoetin and darbepoetin, work in similar ways. Additionally, data from 3 retrospective studies suggest that the use of high-dose epoetin alfa plus iron (with or without vitamin B12 and folic acid supplementation) for perioperative hemoglobin optimization before and after major elective surgery (eg, cardiac, spinal surgery) in patients (eg, Jehovah’s Witnesses) refusing allogeneic blood transfusion is beneficial in this setting [Joseph 2008], [McCartney 2014], [Tanaka 2015]. Do not shake. Anemia due to myelosuppressive chemotherapy in cancer patients: Note: Initiate treatment only if hemoglobin <10 g/dL and anticipated duration of myelosuppressive chemotherapy is ≥2 months. • Seizures: The risk for seizures is increased with epoetin alfa product use in patients with CKD; use with caution in patients with a history of seizures.
Monitor therapy, Nandrolone: May enhance the stimulatory effect of Erythropoiesis-Stimulating Agents. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10 000 mU/mL) include any anemia, and hypoxemiadue to chronic lung d… Discontinue following the completion of a chemotherapy course. - Exclude other causes of anaemia and give iron supplements where appropriate.
Do not use this medicine (epoetin alfa vials) if you are pregnant.
- Interrupt treatment if blood pressure becomes uncontrollable. Do not re-enter vial; discard unused portions. Have blood work checked as you have been told by the doctor.
• Perisurgery patients: [US Boxed Warning]: Deep vein thrombosis (DVT) prophylaxis is recommended in perisurgery patients due to the increased risk of DVT. *Contact Medical Information. During ESA treatment, assess iron status with total iron-binding capacity, and transferrin saturation or ferritin levels. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Anemia in chronic kidney disease (ON dialysis): Note: The IV route is preferred for hemodialysis patients; initiate treatment when hemoglobin is <10 g/dL; reduce dose or interrupt treatment if hemoglobin approaches or exceeds 12 g/dL (if age ≤16 years) or 11 g/dL (if age >16 years): Infants, Children, and Adolescents ≤16 years: IV, SubQ: 50 units/kg/dose 3 times weekly, Adolescents >16 years: IV, SubQ: 50 to 100 units/kg/dose 3 times weekly, If hemoglobin does not increase by >1 g/dL after 4 weeks: Increase dose by 25%; do not increase the dose more frequently than once every 4 weeks, If hemoglobin increases >1 g/dL in any 2-week period: Reduce dose by ≥25%; dose reductions can occur more frequently than once every 4 weeks; avoid frequent dosage adjustments. Read it again each time this medicine (epoetin alfa vials) is
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